Description
The bioactive tetrapeptide goralatide which corresponds to the N-terminus of Thymosin β₄, is a physiological regulator of hematopoiesis and inhibits the entry into the S-phase of murine and human hematopoietic stem cells. Ac-SDKP has been shown to reduce the damage to specific compartments in the bone marrow resulting from treatment with chemotherapeutic agents, ionizing radiations, hyperthermy, or phototherapy. It protects from doxorubicin-induced toxicity. Ac-SDKP is a physiological substrate of angiotensin I- converting enzyme (ACE).
GPS Number: 100
Also known as: AcSDKP, Stem Cell Proliferation Inhibitor, Goralatide
One Letter Code: Ac-SDKP-OH
Three letter code: Ac-Ser-Asp-Lys-Pro-OH
Molecular Formula: C₂₀H₃₃N₅O₉
Molecular weight: 487.51
CAS Registry Number: [127103-11-1]
Source: Synthetic
Storage Conditions: -20 ± 5 °C
